A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.

The discovery of GTPase-inhibiting mutations in genes for alpha subunits of Gs or G(i2) in certain human endocrine tumors has raised the possibility that heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) might contribute to neoplastic disease. Expression of GTPase-deficient...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Xu, N, Bradley, L, Ambdukar, I, Gutkind, J S
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8393576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6741
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!