A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.
The discovery of GTPase-inhibiting mutations in genes for alpha subunits of Gs or G(i2) in certain human endocrine tumors has raised the possibility that heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) might contribute to neoplastic disease. Expression of GTPase-deficient...
Na minha lista:
| 發表在: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1993
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8393576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6741 |
| 標簽: |
沒有標簽, 成為第一個標記此記錄!
|