Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

Altered brain metabolism is associated with progression of Alzheimer’s Disease (AD). Mitochondria respond to bioenergetic changes by continuous fission and fusion. To account for three dimensional architecture of the brain tissue and organelles, we applied 3-dimensional electron microscopy (3D EM) r...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Liang, Trushin, Sergey, Christensen, Trace A., Bachmeier, Benjamin V., Gateno, Benjamin, Schroeder, Andreas, Yao, Jia, Itoh, Kie, Sesaki, Hiromi, Poon, Wayne W., Gylys, Karen H., Patterson, Emily R., Parisi, Joseph E., Diaz Brinton, Roberta, Salisbury, Jeffrey L., Trushina, Eugenia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700525/
https://ncbi.nlm.nih.gov/pubmed/26729583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18725
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