Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

BACKGROUND: The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve monitoring and predicting of AD progression. Mitochondrial dysfunction has been suggested to underlie AD pathophysiology, howev...

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Detalhes bibliográficos
Main Authors: Trushina, Eugenia, Nemutlu, Emirhan, Zhang, Song, Christensen, Trace, Camp, Jon, Mesa, Janny, Siddiqui, Ammar, Tamura, Yasushi, Sesaki, Hiromi, Wengenack, Thomas M., Dzeja, Petras P., Poduslo, Joseph F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290628/
https://ncbi.nlm.nih.gov/pubmed/22393443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032737
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