EBP50 induces apoptosis in macrophages by upregulating nitric oxide production to eliminate intracellular Mycobacterium tuberculosis

Mycobacterium bovis BCG is known to have the capacity to inhibit the positioning of iNOS on BCG-containing phagosomes by interfering with EBP50, a scaffolding protein that controls the recruitment of inducible nitric oxide synthase (iNOS) at the vicinity of phagosomes in macrophages. However, knockd...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Guo, Yang, Deng, Yating, Huang, Zikun, Luo, Qing, Peng, Yiping, Chen, Jie, Jiang, Hong, Ye, Jianqing, Li, Junming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700441/
https://ncbi.nlm.nih.gov/pubmed/26729618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18961
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