Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes

A major unmet clinical need is a universal method for subcellular targeting of bioactive molecules to lysosomes. Delivery to this organelle enables either degradation of oncogenic receptors that are overexpressed in cancers, or release of prodrugs from antibody–drug conjugates. Here, we describe a g...

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Publicat a:Mol Ther
Autors principals: Moody, Paul R, Sayers, Edward J, Magnusson, Johannes P, Alexander, Cameron, Borri, Paola, Watson, Peter, Jones, Arwyn T
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700114/
https://ncbi.nlm.nih.gov/pubmed/26412588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.178
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