Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes

A major unmet clinical need is a universal method for subcellular targeting of bioactive molecules to lysosomes. Delivery to this organelle enables either degradation of oncogenic receptors that are overexpressed in cancers, or release of prodrugs from antibody–drug conjugates. Here, we describe a g...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Moody, Paul R, Sayers, Edward J, Magnusson, Johannes P, Alexander, Cameron, Borri, Paola, Watson, Peter, Jones, Arwyn T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700114/
https://ncbi.nlm.nih.gov/pubmed/26412588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.178
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