Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes

A major unmet clinical need is a universal method for subcellular targeting of bioactive molecules to lysosomes. Delivery to this organelle enables either degradation of oncogenic receptors that are overexpressed in cancers, or release of prodrugs from antibody–drug conjugates. Here, we describe a g...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther
Auteurs principaux: Moody, Paul R, Sayers, Edward J, Magnusson, Johannes P, Alexander, Cameron, Borri, Paola, Watson, Peter, Jones, Arwyn T
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700114/
https://ncbi.nlm.nih.gov/pubmed/26412588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.178
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