Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors

Recombinant adeno-associated virus serotype 3B (rAAV3B) can transduce cultured human liver cancer cells and primary human hepatocytes efficiently. Serine (S)- and threonine (T)-directed capsid modifications further augment its transduction efficiency. Systemically delivered capsid-optimized rAAV3B v...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Li, Shaoyong, Ling, Chen, Zhong, Li, Li, Mengxin, Su, Qin, He, Ran, Tang, Qiushi, Greiner, Dale L, Shultz, Leonard D, Brehm, Michael A, Flotte, Terence R, Mueller, Christian, Srivastava, Arun, Gao, Guangping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700112/
https://ncbi.nlm.nih.gov/pubmed/26403887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.174
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