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Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.

NF1 was first identified as the gene responsible for the pathogenesis of the human genetic disorder neurofibromatosis type 1. cDNA cloning revealed that its putative protein product has a domain showing significant sequence homology with the mammalian Ras GTPase activating protein and two yeast Sacc...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nakafuku, M, Nagamine, M, Ohtoshi, A, Tanaka, K, Toh-e, A, Kaziro, Y
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47001/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8341688/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6706
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