Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the matrix remodeling, invasion, angiogenesis, and tumor-growth-promoting abilities...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Calvo, Fernando, Ranftl, Romana, Hooper, Steven, Farrugia, Aaron J., Moeendarbary, Emad, Bruckbauer, Andreas, Batista, Facundo, Charras, Guillaume, Sahai, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700053/
https://ncbi.nlm.nih.gov/pubmed/26711338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.052
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