Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes

Human mesenchymal stem cells (MSCs) modified by targeting DNA hypermethylation of genes in the Salvador/Warts/Hippo pathway were induced to differentiate into neuronal cells in vitro. The differentiated cells secreted a significant level of brain-derived neurotrophy factor (BDNF) and the expression...

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Veröffentlicht in:PLoS One
Hauptverfasser: Tzeng, Hui-Hung, Hsu, Chi-Hung, Chung, Ting-Hao, Lee, Wen-Chien, Lin, Chi-Hsien, Wang, Wan-Chen, Hsiao, Chen-Yu, Leu, Yu-Wei, Wang, Tzu-Hsien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699852/
https://ncbi.nlm.nih.gov/pubmed/26713735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145542
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