Accumulation of Aspartic Acid(421)- and Glutamic Acid(391)-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

Truncations of tau protein at aspartic acid(421) (D(421)) and glutamic acid(391) (E(391)) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients. Using immunohistochemistry with antibodies to D(421)- and E(391)-truncated tau (Tau-C3 and MN423, re...

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Bibliographic Details
Published in:J Neuropathol Exp Neurol
Main Authors: Basurto-Islas, Gustavo, Luna-Muñoz, Jose, Guillozet-Bongaarts, Angela L., Binder, Lester I., Mena, Raul, García-Sierra, Francisco
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699801/
https://ncbi.nlm.nih.gov/pubmed/18431250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e31817275c7
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