Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis

Glycogen synthase kinase-3β (GSK-3β) regulates the sequential activation of caspase-2 and caspase-8 before mitochondrial apoptosis. Here, we report the regulation of Mcl-1 destabilization and cathepsin D-regulated caspase-8 activation by GSK-3β and caspase-2. Treatment with either the ceramide analo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lin, Chiou-Feng, Tsai, Cheng-Chieh, Huang, Wei-Ching, Wang, Yu-Chih, Tseng, Po-Chun, Tsai, Tsung-Ting, Chen, Chia-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699703/
https://ncbi.nlm.nih.gov/pubmed/26727221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145460
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