Alliance A091103 a phase II study of the angiopoietin 1 and 2 peptibody trebananib for the treatment of angiosarcoma

INTRODUCTION: Angiosarcomas are rare malignant endothelial cell tumors which have up-regulation of the angiopoietin system [e.g., Tie2 and Angiopoietin 2 (Ang2)]. Trebananib is a novel agent targeting Angiopoietin 1 and Angiopoietin 2. METHODS: Trebananib 30 mg/kg was administered weekly until progr...

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Udgivet i:Cancer Chemother Pharmacol
Main Authors: D’Angelo, Sandra P., Mahoney, Michelle R., Van Tine, Brian A., Adkins, Douglas R., Grosse Perdekamp, Maria T., Condy, Mercedes M., Luke, Jason J., Hartley, Eliza Woodward, Antonescu, Cristina R., Tap, William D., Schwartz, Gary K.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699670/
https://ncbi.nlm.nih.gov/pubmed/25672915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2689-8
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