Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

AMG 386 is an investigational first-in-class peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the interaction of angiopoietin-1 (Ang1) and Ang2 with their receptor, Tie2. Although the therapeutic value of blocking Ang2 has been shown in several models of tumorigenesis a...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Coxon, Angela, Bready, James, Min, Hosung, Kaufman, Stephen, Leal, Juan, Yu, Dongyin, Lee, Tani Ann, Sun, Ji-Rong, Estrada, Juan, Bolon, Brad, McCabe, James, Wang, Ling, Rex, Karen, Caenepeel, Sean, Hughes, Paul, Cordover, David, Kim, Haejin, Han, Seog Joon, Michaels, Mark L., Hsu, Eric, Shimamoto, Grant, Cattley, Russell, Hurh, Eunju, Nguyen, Linh, Wang, Shao Xiong, Ndifor, Anthony, Hayward, Isaac J., Falcón, Beverly L., McDonald, Donald M., Li, Luke, Boone, Tom, Kendall, Richard, Radinsky, Robert, Oliner, Jonathan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430860/
https://ncbi.nlm.nih.gov/pubmed/20937592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0213
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