Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

AMG 386 is an investigational first-in-class peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the interaction of angiopoietin-1 (Ang1) and Ang2 with their receptor, Tie2. Although the therapeutic value of blocking Ang2 has been shown in several models of tumorigenesis a...

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Publicado en:Mol Cancer Ther
Autores principales: Coxon, Angela, Bready, James, Min, Hosung, Kaufman, Stephen, Leal, Juan, Yu, Dongyin, Lee, Tani Ann, Sun, Ji-Rong, Estrada, Juan, Bolon, Brad, McCabe, James, Wang, Ling, Rex, Karen, Caenepeel, Sean, Hughes, Paul, Cordover, David, Kim, Haejin, Han, Seog Joon, Michaels, Mark L., Hsu, Eric, Shimamoto, Grant, Cattley, Russell, Hurh, Eunju, Nguyen, Linh, Wang, Shao Xiong, Ndifor, Anthony, Hayward, Isaac J., Falcón, Beverly L., McDonald, Donald M., Li, Luke, Boone, Tom, Kendall, Richard, Radinsky, Robert, Oliner, Jonathan D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430860/
https://ncbi.nlm.nih.gov/pubmed/20937592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0213
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