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Polymorphs of Theophylline Characterized by DNP Enhanced Solid-State NMR

[Image: see text] We show how dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy can be used to characterize polymorphs and solvates of organic solids. We applied DNP to three polymorphs and one hydrated form of the asthma drug molecule theophylline. For some forms of theophyll...

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Publicado en:Mol Pharm
Autores principales: Pinon, Arthur C., Rossini, Aaron J., Widdifield, Cory M., Gajan, David, Emsley, Lyndon
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2015
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699642/
https://ncbi.nlm.nih.gov/pubmed/26393368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00610
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