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Polymorphs of Theophylline Characterized by DNP Enhanced Solid-State NMR

[Image: see text] We show how dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy can be used to characterize polymorphs and solvates of organic solids. We applied DNP to three polymorphs and one hydrated form of the asthma drug molecule theophylline. For some forms of theophyll...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Pinon, Arthur C., Rossini, Aaron J., Widdifield, Cory M., Gajan, David, Emsley, Lyndon
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699642/
https://ncbi.nlm.nih.gov/pubmed/26393368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00610
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