Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria

PURPOSE: Cell death in neurodegeneration occurs at the convergence of diverse metabolic pathways. In the retina, a common underlying mechanism involves mitochondrial dysfunction since photoreceptor homeostasis and survival are highly susceptible to altered aerobic energy metabolism. We sought to dev...

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Bibliografische gegevens
Gepubliceerd in:Invest Ophthalmol Vis Sci
Hoofdauteurs: Kooragayala, Keshav, Gotoh, Norimoto, Cogliati, Tiziana, Nellissery, Jacob, Kaden, Talia R., French, Stephanie, Balaban, Robert, Li, Wei, Covian, Raul, Swaroop, Anand
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Association for Research in Vision and Ophthalmology 2015
Onderwerpen:
Biochemistry and Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699410/
https://ncbi.nlm.nih.gov/pubmed/26747773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17901
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