Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling

BACKGROUND: Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. RESULTS: We examined the effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After co...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Zannas, Anthony S., Arloth, Janine, Carrillo-Roa, Tania, Iurato, Stella, Röh, Simone, Ressler, Kerry J., Nemeroff, Charles B., Smith, Alicia K., Bradley, Bekh, Heim, Christine, Menke, Andreas, Lange, Jennifer F., Brückl, Tanja, Ising, Marcus, Wray, Naomi R., Erhardt, Angelika, Binder, Elisabeth B., Mehta, Divya
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699359/
https://ncbi.nlm.nih.gov/pubmed/26673150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0828-5
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