Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling

BACKGROUND: Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. RESULTS: We examined the effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After co...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Zannas, Anthony S., Arloth, Janine, Carrillo-Roa, Tania, Iurato, Stella, Röh, Simone, Ressler, Kerry J., Nemeroff, Charles B., Smith, Alicia K., Bradley, Bekh, Heim, Christine, Menke, Andreas, Lange, Jennifer F., Brückl, Tanja, Ising, Marcus, Wray, Naomi R., Erhardt, Angelika, Binder, Elisabeth B., Mehta, Divya
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699359/
https://ncbi.nlm.nih.gov/pubmed/26673150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0828-5
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