Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

INTRODUCTION: Ex vivo experiments in extracorporeal membrane oxygenation (ECMO) circuits have identified octanol-water partition coefficient (logP, a marker of lipophilicity) and protein binding (PB) as key drug factors affecting pharmacokinetics (PK) during ECMO. Using ovine models, in this study w...

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Detalhes bibliográficos
Publicado no:Crit Care
Main Authors: Shekar, Kiran, Roberts, Jason A., Barnett, Adrian G., Diab, Sara, Wallis, Steven C., Fung, Yoke L., Fraser, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699331/
https://ncbi.nlm.nih.gov/pubmed/26667471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-015-1151-y
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