Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study

INTRODUCTION: Vital drugs may be degraded or sequestered in extracorporeal membrane oxygenation (ECMO) circuits, with lipophilic drugs considered to be particularly vulnerable. However, the circuit effects on protein-bound drugs have not been fully elucidated. The aim of this experimental study was...

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Detalhes bibliográficos
Publicado no:Crit Care
Main Authors: Shekar, Kiran, Roberts, Jason A, Mcdonald, Charles I, Ghassabian, Sussan, Anstey, Chris, Wallis, Steven C, Mullany, Daniel V, Fung, Yoke L, Fraser, John F
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407324/
https://ncbi.nlm.nih.gov/pubmed/25888449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-015-0891-z
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