Bryostatin extends tPA time window to 6 hours following middle cerebral artery occlusion in aged female rats

BACKGROUND AND PURPOSE: Blood-brain barrier (BBB) disruption and hemorrhagic transformation (HT) following ischemic/reperfusion injury contributes to post-stroke morbidity and mortality. Bryostatin, a potent protein kinase C (PKC) modulator, has shown promise in treating neurological injury. In the...

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Publicat a:Eur J Pharmacol
Autors principals: Tan, Zhenjun, Lucke-Wold, Brandon P., Logsdon, Aric F., Turner, Ryan C., Tan, Cong, Li, Xinlan, Hongpaison, Jarin, Alkon, Daniel L., Simpkins, James W., Rosen, Charles L., Huber, Jason D.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698807/
https://ncbi.nlm.nih.gov/pubmed/26189021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2015.07.035
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