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Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

WDR5 is a core component of SET1-family complexes that achieve transcriptional activation via methylation of histone H3 on Nζ of Lys4 (H3K4). The role of WDR5 in the MLL1 complex has recently been described as specific recognition of dimethyl-K4 in the context of a histone H3 amino terminus; WDR5 is...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Ruthenburg, Alexander J, Wang, Wooikoon, Graybosch, Daina M, Li, Haitao, Allis, C David, Patel, Dinshaw J, Verdine, Gregory L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698793/
https://ncbi.nlm.nih.gov/pubmed/16829959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1119
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