A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules

A 24-amino acid leader peptide of a new human recombinant manganese superoxide dismutase can enter cells and carry molecules. Here, we demonstrated that six of the 24 amino acids penetrate cells through a particular gate represented by a specific amino acid sequence of the oestrogen receptor (ER). W...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Borrelli, Antonella, Schiattarella, Antonietta, Mancini, Roberto, Pica, Alessandra, Pollio, Maria Laura, Ruggiero, Maria Grazia, Bonelli, Patrizia, De Luca, Viviana, Tuccillo, Franca Maria, Capasso, Clemente, Gori, Enrico, Sanseverino, Marina, Carpentieri, Andrea, Birolo, Leila, Pucci, Piero, Rommelaere, Jean, Mancini, Aldo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698655/
https://ncbi.nlm.nih.gov/pubmed/26725847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18691
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