PKCα regulates TMEM16A-mediated Cl(−) secretion in human biliary cells

TMEM16A is a newly identified Ca(2+)-activated Cl(−) channel in biliary epithelial cells (BECs) that is important in biliary secretion. While extracellular ATP stimulates TMEM16A via binding P2 receptors and increasing intracellular Ca(2+) concentration ([Ca(2+)](i)), the regulatory pathways have no...

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Библиографические подробности
Опубликовано в: :Am J Physiol Gastrointest Liver Physiol
Главные авторы: Dutta, Amal K., Khimji, Al-Karim, Liu, Songling, Karamysheva, Zemfira, Fujita, Akiko, Kresge, Charles, Rockey, Don C., Feranchak, Andrew P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2015
Предметы:
Liver And Biliary Tract Physiology/Pathophysiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698437/
https://ncbi.nlm.nih.gov/pubmed/26542395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00146.2015
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