Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation

The mammalian circadian clock consists of multiple transcriptional regulators that coordinate biological processes in a time-of-day-dependent manner. Cardiomyocyte-specific deletion of the circadian clock component, Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein 1), leads to age-...

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Gepubliceerd in:Am J Physiol Heart Circ Physiol
Hoofdauteurs: Ingle, Kevin A., Kain, Vasundhara, Goel, Mehak, Prabhu, Sumanth D., Young, Martin E., Halade, Ganesh V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698380/
https://ncbi.nlm.nih.gov/pubmed/26432841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00608.2015
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