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Hematopoietic stem and multipotent progenitor cells produce IL-17, IL-21 and other cytokines in response to TLR signals associated with late apoptotic products and augment memory Th17 and Tc17 cells in the bone marrow of normal and lupus mice
We studied effects of early and late apoptotic (necroptotic) cell products, related damage associated alarmins and TLR agonists, on hematopoietic stem and progenitor cells (HSPC).() Surprisingly, normal HSPC themselves produced IL-17 and IL-21 after 1½ days of stimulation, and the best stimulators w...
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| Yayımlandı: | Clin Immunol |
|---|---|
| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698105/ https://ncbi.nlm.nih.gov/pubmed/26521071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.10.007 |
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