The Estrogen Metabolite 16αOHE Exacerbates BMPR2-Associated PAH Through miR-29-Mediated Modulation of Cellular Metabolism

BACKGROUND: Pulmonary arterial hypertension (PAH) is a proliferative disease of the pulmonary vasculature which preferentially affects females. Estrogens, such as the metabolite 16α-hydroxyestrone (16αOHE), may contribute to PAH pathogenesis; and, alterations in cellular energy metabolism associate...

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Publicado en:Circulation
Main Authors: Chen, Xinping, Talati, Megha, Fessel, Joshua P., Hemnes, Anna R., Gladson, Santhi, French, Jaketa, Shay, Sheila, Trammel, Aaron, Phillips, John A., Hamid, Rizwan, Cogan, Joy D., Dawson, Elliott P., Womble, Kristie E., Hedges, Lora K., Martinez, Elizabeth G., Wheeler, Lisa A., Loyd, James E., Majka, Susan J., West, James, Austin, Eric D.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698046/
https://ncbi.nlm.nih.gov/pubmed/26487756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.016133
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