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pH-dependent population shift regulates BACE1 activity and inhibition
BACE1, a major therapeutic target for treatment of Alzheimer’s disease, functions within a narrow pH range. Despite tremendous effort and progress in the development of BACE1 inhibitors, details of the underlying pH-dependent regulatory mechanism remain unclear. Here we elucidate the pH-dependent co...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697946/ https://ncbi.nlm.nih.gov/pubmed/26186663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05891 |
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