Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells

Natural killer (NK) cells play a critical role in controlling murine cytomegalovirus (MCMV) and can mediate both cytokine production and direct cytotoxicity. The NK cell activation receptor, Ly49H, is responsible for genetic resistance to MCMV in C57BL/6 mice. Recognition of the viral m157 protein b...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Parikh, Bijal A., Piersma, Sytse J., Pak-Wittel, Melissa A., Yang, Liping, Schreiber, Robert D., Yokoyama, Wayne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697817/
https://ncbi.nlm.nih.gov/pubmed/26720279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005323
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