Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant

Dengue virus (DENV) is the most common mosquito-transmitted virus infecting ~390 million people worldwide. In spite of this high medical relevance, neither a vaccine nor antiviral therapy is currently available. DENV elicits a strong interferon (IFN) response in infected cells, but at the same time...

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Publicado en:PLoS Pathog
Autores principales: Schmid, Bianca, Rinas, Melanie, Ruggieri, Alessia, Acosta, Eliana Gisela, Bartenschlager, Marie, Reuter, Antje, Fischl, Wolfgang, Harder, Nathalie, Bergeest, Jan-Philip, Flossdorf, Michael, Rohr, Karl, Höfer, Thomas, Bartenschlager, Ralf
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697809/
https://ncbi.nlm.nih.gov/pubmed/26720415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005345
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