Novel Zn(2+) Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents

Type 2 diabetes (T2D) occurs when there is insufficient insulin release to control blood glucose, due to insulin resistance and impaired β-cell function. The GPR39 receptor is expressed in metabolic tissues including pancreatic β-cells and has been proposed as a T2D target. Specifically, GPR39 agoni...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Fjellström, Ola, Larsson, Niklas, Yasuda, Shin-ichiro, Tsuchida, Takuma, Oguma, Takahiro, Marley, Anna, Wennberg-Huldt, Charlotte, Hovdal, Daniel, Fukuda, Hajime, Yoneyama, Yukimi, Sasaki, Kazuyo, Johansson, Anders, Lundqvist, Sara, Brengdahl, Johan, Isaacs, Richard J., Brown, Daniel, Geschwindner, Stefan, Benthem, Lambertus, Priest, Claire, Turnbull, Andrew
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697807/
https://ncbi.nlm.nih.gov/pubmed/26720709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145849
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