Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass

Phospholipase C gamma-2 (PLCγ2)-dependent calcium (Ca(2+)) oscillations are indispensable for nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) activation and downstream gene transcription driving osteoclastogenesis during skeletal remodeling and pathological bone loss. Here we describe, t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Decker, Corinne E., Yang, Zhengfeng, Rimer, Ryan, Park-Min, Kyung-Hyun, Macaubas, Claudia, Mellins, Elizabeth D., Novack, Deborah V., Faccio, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697402/
https://ncbi.nlm.nih.gov/pubmed/26644563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511285112
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