In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations

Acting during phase II metabolism, sulfotransferases (SULTs) serve detoxification by transforming a broad spectrum of compounds from pharmaceutical, nutritional, or environmental sources into more easily excretable metabolites. However, SULT activity has also been shown to promote formation of react...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Rakers, Christin, Schumacher, Fabian, Meinl, Walter, Glatt, Hansruedi, Kleuser, Burkhard, Wolber, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697188/
https://ncbi.nlm.nih.gov/pubmed/26542807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685610
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