Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY

Mitogen-activated protein kinases (MAPK) promote MAPK-activated protein kinase activation. In the MAPK pathway responsible for cell growth, ERK2 initiates the first phosphorylation event on RSK1, which is inhibited by Ca(2+)-binding S100 proteins in malignant melanomas. Here, we present a detailed i...

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Publicat a:J Biol Chem
Autors principals: Gógl, Gergő, Alexa, Anita, Kiss, Bence, Katona, Gergely, Kovács, Mihály, Bodor, Andrea, Reményi, Attila, Nyitray, László
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697148/
https://ncbi.nlm.nih.gov/pubmed/26527685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684928
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