Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis

BACKGROUND: We investigated sera from elderly subjects with and without age-related macular degeneration (AMD) for presence of autoantibodies (AAbs) against human macular antigens and characterized their identity. METHODS: Sera were collected from participants in the Age-Related Maculopathy Ancillar...

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Udgivet i:PLoS One
Main Authors: Iannaccone, Alessandro, Giorgianni, Francesco, New, David D., Hollingsworth, T. J., Umfress, Allison, Alhatem, Albert H., Neeli, Indira, Lenchik, Nataliya I., Jennings, Barbara J., Calzada, Jorge I., Satterfield, Suzanne, Mathews, Dennis, Diaz, Rocio I., Harris, Tamara, Johnson, Karen C., Charles, Steve, Kritchevsky, Stephen B., Gerling, Ivan C., Beranova-Giorgianni, Sarka, Radic, Marko Z.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696815/
https://ncbi.nlm.nih.gov/pubmed/26717306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145323
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