Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

Little is known about how mitotic cells round against epithelial confinement. Here, we engineer micropillar arrays that subject cells to lateral mechanical confinement similar to that experienced in epithelia. If generating sufficient force to deform the pillars, rounding epithelial (MDCK) cells can...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Sorce, Barbara, Escobedo, Carlos, Toyoda, Yusuke, Stewart, Martin P., Cattin, Cedric J., Newton, Richard, Banerjee, Indranil, Stettler, Alexander, Roska, Botond, Eaton, Suzanne, Hyman, Anthony A., Hierlemann, Andreas, Müller, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696517/
https://ncbi.nlm.nih.gov/pubmed/26602832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9872
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