Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate

PURPOSE: Glutamine addiction in c-MYC–overexpressing breast cancer is targeted by the aminotransferase inhibitor, aminooxyacetate (AOA). However, the mechanism of ensuing cell death remains unresolved. EXPERIMENTAL DESIGN: A correlation between glutamine dependence for growth and c-MYC expression wa...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Korangath, Preethi, Teo, Wei Wen, Sadik, Helen, Han, Liangfeng, Mori, Noriko, Huijts, Charlotte M., Wildes, Flonne, Bharti, Santosh, Zhang, Zhe, Santa-Maria, Cesar A., Tsai, Hualing, Dang, Chi V., Stearns, Vered, Bhujwalla, Zaver M., Sukumar, Saraswati
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696069/
https://ncbi.nlm.nih.gov/pubmed/25813021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1200
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