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Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine,...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4695385/ https://ncbi.nlm.nih.gov/pubmed/26499495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09436 |
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