Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine,...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hettmer, Simone, Schinzel, Anna C, Tchessalova, Daria, Schneider, Michaela, Parker, Christina L, Bronson, Roderick T, Richards, Nigel GJ, Hahn, William C, Wagers, Amy J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695385/
https://ncbi.nlm.nih.gov/pubmed/26499495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09436
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