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Benzene Oxide is a Substrate for Glutathione S-Transferases

Benzene is a known human carcinogen which must be activated to benzene oxide (BO) to exert its carcinogenic potential. BO can be detoxified in vivo by reaction with glutathione and excretion in the urine as S-phenylmercapturic acid. This process may be catalyzed by glutathione S-transferases (GSTs),...

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Bibliographic Details
Published in:Chem Biol Interact
Main Authors: Zarth, Adam T., Murphy, Sharon E., Hecht, Stephen S.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695229/
https://ncbi.nlm.nih.gov/pubmed/26554337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2015.11.005
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