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Fluorogenic Sialic acid Glycosides for Quantification of Sialidase Activity Upon Unnatural Substrates
Herein we report the synthesis of N-acetyl neuraminic acid derivatives as 4-methylumbelliferyl glycosides and their use in fluorometrically quantifying human and bacterial sialidase activity and substrate specificities. We found that sialidases in the human promyelocytic leukemic cell line HL60 were...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4695216/ https://ncbi.nlm.nih.gov/pubmed/23639536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.076 |
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