RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

PURPOSE: The miniature biodegradable implant siG12D-LODER™ was inserted into a tumor and released a siRNA drug against KRAS(G12D) along four months. This novel siRNA based drug was studied, in combination with chemotherapy, as targeted therapy for Locally Advanced Pancreatic Cancer (LAPC). METHODS:...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Golan, Talia, Khvalevsky, Elina Zorde, Hubert, Ayala, Gabai, Rachel Malka, Hen, Naama, Segal, Amiel, Domb, Abraham, Harari, Gil, David, Eliel Ben, Raskin, Stephen, Goldes, Yuri, Goldin, Eran, Eliakim, Rami, Lahav, Maor, Kopleman, Yael, Dancour, Alain, Shemi, Amotz, Galun, Eithan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Clinical Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695206/
https://ncbi.nlm.nih.gov/pubmed/26009994
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