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Mutant KRAS is a druggable target for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) represents an unmet therapeutic challenge. PDA is addicted to the activity of the mutated KRAS oncogene which is considered so far an undruggable therapeutic target. We propose an approach to target KRAS effectively in patients using RNA interference. To meet t...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870687/ https://ncbi.nlm.nih.gov/pubmed/24297898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314307110 |
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