Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

DNA polymerase beta (Pol β) is a key enzymefor the protection against oxidative DNA lesions via itsrole in base excision repair (BER). Approximately 1/3 of tumors studied to date express Pol β variant proteins, and several tumors overexpress Pol β. Pol β possesses DNA polymerase and dRP lyase activi...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Rozacky, Jenna, Nemec, Antoni A., Sweasy, Joann B., Kidane, Dawit
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695199/
https://ncbi.nlm.nih.gov/pubmed/26090616
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