Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents

Overexpression of ATP-Binding Cassette transporters leads to multidrug resistance in cancer cells and results in the failure of chemotherapy. In this in-vitro study, we investigated whether or not (20S, 24R/S)-epoxy-12β, 25-dihydroxy-dommarane-3β-amine (ORA and OSA), a pair of semi-synthetic ocotill...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Yun-Kai, Zhang, Hengyuan, Zhang, Guan-Nan, Wang, Yi-Jun, Kathawala, Rishil J., Si, Rui, Patel, Bhargav A., Xu, Jinyi, Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695185/
https://ncbi.nlm.nih.gov/pubmed/26296969
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