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Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells

Doxorubicin (Doxo) is one of the most widely used chemotherapeutic drugs for patients with hepatocellular carcinoma (HCC). Doxo is a DNA intercalating drug that inhibits topoisomerase II. Thereby Doxo has the ability to block DNA replication and induce apoptosis. However, the other targets and mecha...

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Publicat a:Oncotarget
Autors principals: Wang, Jiayi, Ma, Lifang, Tang, Xun, Zhang, Xiao, Qiao, Yongxia, Shi, Yuling, Xu, Yanfeng, Wang, Zhongyong, Yu, Yongchun, Sun, Fenyong
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695171/
https://ncbi.nlm.nih.gov/pubmed/26124182
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