Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells

Doxorubicin (Doxo) is one of the most widely used chemotherapeutic drugs for patients with hepatocellular carcinoma (HCC). Doxo is a DNA intercalating drug that inhibits topoisomerase II. Thereby Doxo has the ability to block DNA replication and induce apoptosis. However, the other targets and mecha...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Jiayi, Ma, Lifang, Tang, Xun, Zhang, Xiao, Qiao, Yongxia, Shi, Yuling, Xu, Yanfeng, Wang, Zhongyong, Yu, Yongchun, Sun, Fenyong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695171/
https://ncbi.nlm.nih.gov/pubmed/26124182
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