A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies

Tyrosine kinase inhibitors (TKI) have improved CML response rates, and some are effective against resistance-promoting point mutations in BCR-ABL1. However, in the absence of point mutations, resistance still occurs. Here, we identify a novel pathway mediating resistance which connects p47phox, the...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Irwin, Mary E., Johnson, Blake P., Manshouri, Roxsan, Amin, Hesham M., Chandra, Joya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695141/
https://ncbi.nlm.nih.gov/pubmed/26136341
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